Monitoring drug therapy

ABC of monitoring drug therapy. Phenytoin.

ABC of monitoring drug therapy. Theophylline.

It is not possible to establish a single dosage regimen for theophylline or its derivatives (for example, aminophylline) that will suit all patients because the metabolism of theophylline varies greatly from person to person. This variation is reflected in its elimination half life, which varies from four hours in healthy adult smokers to about 25 hours in patients with hepatic cirrhosis. Sever...

ABC of monitoring drug therapy. Cyclosporin.

range of other conditions, including Another important aspect in its distribution is that it is highly bound to psoriasis, rheumatoid arthritis, and erythrocytes and plasma lipoproteins. At low blood concentrations (below asthma 80 nmolIl (100 ng/ml)) and when the packed cell volume is low (for example, in patients with kidney failure) the contribution of the plasma bound fraction becomes more ...

ABC of monitoring drug therapy. Digoxin.

The plasma digoxin concentration that will result from a given dose of the drug can be predicted at best with only 34% accuracy, although knowledge of a previous concentration improves the ability to predict subsequent concentrations. In outpatients taking a fixed daily dosage, a steady state plasma digoxin concentrations vary widely (between 0 5 and 3 5 nmol/l). This means that if a target pla...

therapeutic drug monitoring

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